Great news for sufferers of Crohn’s disease: new drug found to work!

Crohn’s disease can be debilitating and painful, so this is happy news indeed.

Via microsoft translate from Deredactie.be:

‘Those patients will now be able to be helped with Vedolizumab in the foreseeable future. So hot the new drug that blocks lymphocytes. That are white blood cells that in these patients flock to the intestine and cause inflammation.

Although medicines existed acting on lymphocytes, but those held in unacceptable risks because they not only the migration to the intestine, but also blocked to the brain. That often resulted in severe brain disorders.

“With the new drug, we managed to selectively block the migration of lymphocytes and to avoid these harmful side effects,” said gastro-enterologe Séverine Vermeire UZ Leuven.

It is expected that the drug in the course of next year will come on the European market.’

The Lycurgus Cup – 1,600-Year-Old Goblet Shows that the Romans Were Nanotechnology Pioneers

A fascinating article from Smithsonian.com explains why this 4th century C.E. cup appears jade coloured when lit from the front, but red when lit from behind:  it’s all in the Roman’s mastery of nanotech:

‘The ancient nanotech works something like this: When hit with light, electrons belonging to the metal flecks vibrate in ways that alter the color depending on the observer’s position. Gang Logan Liu, an engineer at the University of Illinois at Urbana-Champaign, who has long focused on using nanotechnology to diagnose disease, and his colleagues realized that this effect offered untapped potential. “The Romans knew how to make and use nanoparticles for beautiful art,” Liu says. “We wanted to see if this could have scientific applications.”

When various fluids filled the cup, Liu suspected, they would change how the vibrating electrons in the glass interacted, and thus the color. (Today’s home pregnancy tests exploit a separate nano-based phenomenon to turn a white line pink.)’

Read the full article: http://www.smithsonianmag.com/history-archaeology/This-1600-Year-Old-Goblet-Shows-that-the-Romans-Were-Nanotechnology-Pioneers-220563661.html#ixzz2colO2wpQ

Tinfoil-hat time: embedding false memories using blue light is now a reality

Yes – what seemed far-fetched sci-fi plots is now a reality, if, for the time being, only for mice.

‘The researchers used optogenetics, a technique that allows precise control of brain circuits. The control is achieved by expressing proteins that act as switches in particular types of brain cells. These switches are channels that, when struck by a particular color of light, allow charged particles into or out of the neurons, which will either activate or silence them.’

‘Armed with this discovery, they installed the optogenetic trigger in the neurons that were especially busy while a mouse got to know a new environment (we’ll call that Place A). The next day, in a different environment, they gave the mouse small electric shocks while triggering the memory of Place A using light. After that, even though it never had a negative experience in Place A itself, the mouse froze when it was returned there.’

What the researchers did was to target a memory of ‘place A’, where the mice had no unpleasant experience, at a later date and use a blue light and electric shock to change that neutral memory into a terrifying one.

Think of that next time you feel a strong aversion to something or an unspecified feeling of uneasiness – and keep the light-reflecting tinfoil hats on!

Thunderf00t: Cesium, the most reactive Alkalai metal

Hubble finds a new Neptune moon

Exciting news!

‘NASA’s Hubble Space Telescope has discovered a new moon orbiting the distant blue-green planet Neptune. This brings the number of known satellites circling the giant planet to 14.

The body is estimated to be no more than 12 miles across, making it the smallest known moon in the Neptunian system. It’s so small that it escaped detection by NASA’s Voyager 2 spacecraft, which flew by Neptune in 1989 and surveyed the planet’s system of moons and rings.’

Read the full press-release here.

Posted in society. Tags: . 1 Comment »

Catching up…

Here are some links to articles I wish I could blog about, but just cannot seem to catch up enough to do so

And, in ‘awesome’ news:

A silver bullet to fight bacteria?

Well, almost…

‘Like werewolves and vampires, bacteria have a weakness: silver. The precious metal has been used to fight infection for thousands of years — Hippocrates first described its antimicrobial properties in 400 bc — but how it works has been a mystery. Now, a team led by James Collins, a biomedical engineer at Boston University in Massachusetts, has described how silver can disrupt bacteria, and shown that the ancient treatment could help to deal with the thoroughly modern scourge of antibiotic resistance. The work is published today in Science Translational Medicine1.’

Posted in science. Tags: , . 1 Comment »

June 22, 2013 – Help Measure the Size of the Earth

 

US Supreme Court Ruling: naturally occuring DNA cannot be patented, but synthesized DNA can

The full ruling can be found here.

While I have not had a chance to study the ruling in detail yet, I have no illusions that my non-legally-trained mind would be able to grasp all of the nuances of the ruling, so, please, do read it for yourself.

In the meantime, this is what the news folks are saying about it:

The Sydney Morning Herald:

‘The US Supreme Court has issued a potentially far-reaching ruling, stating that DNA in the human genome is a “product of nature” that cannot be patented.

The nine-member court’s unanimous finding on Thursday overturns exclusive rights to use genes that have been issued in recent decades by the US Patent and Trademark Office, but does allow companies to patent their developments of synthetic, so-called composite DNA.

“A naturally occurring DNA segment is a product of nature and not patent-eligible merely because it has been isolated,” wrote Justice Clarence Thomas, author of the decision. 

However, he went on to write that composite DNA “is patent-eligible because it is not naturally occurring”.

The decision strikes down patents issued to Myriad Genetics, which had isolated a rare gene associated with very high rates of breast and ovarian cancer in women who carry the mutation. The company had claimed the exclusive right to offer tests for the gene, based on its patent.’

Of course, this patenting of the naturally-occurring cancer genes has been the highest obstacle in cancer research and even cancer treatment, as per many medical professionals.  If you had a naturally occurring breast cancer,  you yourself could not use your own tissue to try to get better, because someone else held a patent on the DNA that had naturally occurred inside of you!
Frankly, that sounds to me like slavery by another name – and I am glad that the US Supreme Court has struck it down! It corrects some (no, not all, but you have to start somewhere) of the incredible patents irresponsibly (and, hopefully ignorantly) granted by the US Patent Office.
More sources…here is what BBC is saying:

‘The opinion said DNA came from nature and was not eligible for patenting.The US biotechnology industry had warned any blanket ban on such patents would jeopardise huge investment in gene research and therapies.

“We hold that a naturally occurring DNA segment is a product of nature and not patent eligible merely because it has been isolated,” Justice Clarence Thomas wrote in Thursday’s opinion.

But his ruling said that synthetic molecules known as complementary DNA can be patented “because it is not naturally occurring”.’

And from The Blaze:

‘For more than 30 years, the  U.S. Patent and Trademark Office has been awarding patents on human genes. But Thursday the U.S. Supreme Court ruled that a patent could not be placed on naturally occurring human genes, because researchers didn’t “create” them.

Those who are praising the decision believe it will benefit both the progress of research and protect the human body  ”from the assertion of private property rights.”’

Considering that over quarter of human DNA had been patented, this is an important ruling indeed!

CodeSlinger on Combinatorics

A couple of days ago, I mentioned to CodeSlinger that one of my sons was doing research in the branch of Mathematics known as ‘Combinatorics‘.  His response was not only informative, it was just as passionate as my son gets when he talks about the subject. 

So, for your pleasure and elucidation, here is CodeSlinger’s commentary on Combinatorics:

Combinatorics… the art of counting.  Hah.  Sounds trivial.  But it is slowly becoming clear that combinatorics lies at the root of everything.
Everything.
The fundamental equations of physics are symmetrical in time – if we watch a movie of two particles coming in from infinity, bouncing off each other, and proceeding back towards infinity, we have no way to determine whether or not we are watching it backwards.  Yet a movie in which a vase falls from the table and shatters on the floor is easily distinguishable from the time-reversed version, in which a myriad of shards come flying together, assemble themselves into a vase, and jump up onto the table!
The difference, of course, is that there are many ways for the shards to be distributed about the floor, but only one way for them to be assembled into a vase.  And that difference is the essence of… counting.  This leads us to the second law of thermodynamics: entropy increases with time.  Or, if you prefer, systems evolve towards states of higher probability.  But probability is nothing other than a relative count of possibilities.  Counting again.
Without counting, there is no arrow of time.
But it gets better.  The whole idea of counting presupposes the existence of things to count.  Which requires us to draw distinctions.  And indeed, we find that distinction is the fundamental act by which something comes out of nothing.  Assuming that a distinction can spontaneously arise out of the void, it will do so – because there are more ways for the void to be cloven than for it to be whole.  Counting again.
If we picture a distinction as a boundary in a space – a closed curve in the plane, a closed surface in space, and so on, then we see that the lowest number of dimensions in which a boundary can assume a configuration that cannot shrink to nothing is… three (the simplest such configuration is the trefoil knot).  Thus we see hints of how a universe of 3 spatial dimensions and one time dimension can spontaneously arise out of nothing.  All because of counting.
Similar considerations explain how this universe comes to contain fundamental particles, and why the have the properties they do.  And ultimately, why consciousness is possible.  All of human feeling can be reduced to drawing or perceiving distinctions, and all of human thought can be reduced to classifying and counting them.
Thus we have the age-old question of which is more fundamental: mathematics or logic.  For centuries men have been trying to derive one from the other.  Finally, a little-known genius by the name of George Spencer-Brown settled it by showing that you cannot derive mathematics from logic, and you cannot derive logic from mathematics.  But there is a more fundamental system, which he called the Laws of Form, from which you can derive both.
He begins with one primal element, which can be viewed as an entity (a distinction) or an action (drawing a distinction).  A boundary can be seen as a way of naming the interior (calling), or as an injunction to cross into the interior (crossing).  Having drawn a distinction, we can draw another one, either beside the first (recalling), or around the first (recrossing).  On this base he lays down two laws, as follows
The law of calling: recalling is the same as calling.
The law of crossing: recrossing is the same as not crossing.
If we denote a boundary as (), then recalling is ()() and recrossing is (()), and we can write these two laws very succinctly as
()() = ()
(()) =
where the right hand side of the second equation is literally empty, denoting the void.
And from this basis, utterly brilliant in its irreducible simplicity, he derives all of mathematics and symbolic logic:

Spencer-Brown, G, 1969: Laws of Form, London: George Allen & Unwin.

But this is only the beginning of the story.  Frederick Parker-Rhodes asked what happens when you repeatedly draw a distinction and get a multitude of identical entities.  From this, he developed a calculus of distinct but indistinguishable entities:
 

Parker-Rhodes, A F, 1981: The Theory of Indistinguishables: A search for explanatory principles below the level of physics, Synthese Library, vol. 150, Springer.

And on that, he constructed what he called the Combinatorial Hierarchy – system whereby the spontaneous emergence of distinctions from the void leads to… the standard model of particle physics.  Astounding!  Even more astounding, he never published this work!  It was finally published for him posthumously by John Amson (see linked pdf):
 

Parker-Rhodes, A F, & Amson, J C, 1998: Hierarchies of descriptive levels in physical theory.  Int’l J. Gen. Syst. 27(1-3):57-80.

The construction he outlines in this paper was implemented as a computer program by H. Pierre Noyes and David McGoveran (again, see linked pdf):
 

Noyes, H P, & McGoveran, D O, 1989: An essay on discrete foundations for physics.  SLAC-PUB-4528.

So when I say that combinatorics lies at the root of everything, I really do mean everything!
It is brilliant!